뇌질환의 혁신, 뉴로벤티(NeuroVenti)

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Realization of brain well-being society through treatment of
intractable brain diseases and utilization of optimal brain functions

Animal models for neurological disorders

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ASD 자폐증
  • Genetic : AGMAT Tg, CNTNAP2 KO, Fmr1 KO mice
  • Chemical : VPA/Poly(I:C)-injection
ADHD ADHD
  • Genetic: SHR, Fmr1 KO mice
  • Chemical: EtOH/MK-801
Depression 우울증
  • Acute restrainer stress/Chronic mild stress, Maternal deprivation
  • LPS-injected model
Schizophrenia 조현병
  • MK-801/PCP/amphetamine/Poly(I:C)-injection
  • Social stress model (social isolation, social defeat)
AD/Dementia 알츠하이머병
  • Genetic: 5xFAD Tg mice
  • Aβ injection, scopolamine/LPS injection, DM-induced dementia model, BCCAO
PD 파킨슨병
  • 6-OHDA/rotenone/MPTP injection
  • α-synuclein overexpression
Stroke 뇌졸증
  • MCAO, photothrombosis-induced model, ET-1/Hemin injection, autologous blood injection
Target disease in vivo models References
Genetic modification Environmental factors
Autism spectrum disorder AGMAT OE, CNTNAP2 KO, Fmr1 KO mice Prenatal VPA/Poly(I:C) exposure
  • Peñagarikano et al., Cell 2011
  • Gantois et al., Nat Med 2017
  • Kim et al., Neuropsychopharmacol 2019
ADHD SHR, Fmr1 KO mice EtOH/Nicotine/
6-OHDA/MK-801 injection
  • Ha et al., Sci Rep 2020
  • Park et al., Neuropharmacol 2020
  • Kim et al., Neuropsychopharmacol 2019
Depression
  • Acute restrainer stress/Chronic mild stress, Maternal deprivation, LPS/corticosterone-injected model
  • Song AQ et al., 2020
  • Zhao X et al., 2019/Chen M et al., 2018
  • Teissier A et al., 2020
Schizophrenia
  • MK-801/PCP/amphetamine/Poly(I:C)-injection
  • Social stress model (social isolation, social defeat)
  • Bae HJ et al., 2022
  • Bator E et al., 2018
AD/Dementia 5xFAD mice Aβ/scopolamine/LPS injection, DM-induced dementia model, BCCAO
  • Back DB et al., 2017
  • Choi BR et al., 2016
  • Kwon KJ et al., 2015
  • Kim DH et al., 2017, 2020
PD α-synuclein (A537 mutant) overexpression 6-OHDA/rotenone/MPTP injection
  • Musa Mustapha et al., 2021
  • Hao Yu et al., 2021/ Zhang et al., 2022
  • Yea-Hyun Leem et al., 2022
Stroke MCAO, photothrombosis-induced model, ET-1/Hemin injection, autologous blood injection
  • Back DB et al., 2017
  • Whitehead SN et al., 2005
  • Choi DH et al., 2016